A lovely "all suites" hotel located a couple short blocks from Cusco's Plaza de Armas, Casa Cartagena is a unique luxury hotel offering a superb value for high end stays in Cusco. Built in a historic "casona" the property offers 17 well-appointed suites and a full array of services, including a restaurant and spa. Incan stones combine with colonial architecture and a beautiful courtyard sets the scene for a peaceful base for exploration in the former capital of the Incan Empire.

Located in a convenient and central part of Lima's upscale Miraflores neighborhood, the Hilton is one of our favorite high-end hotels in the city. Rooms are spacious and well-appointed and prices are extremely reasonable for a 5-star city hotel. There are fancier options available for those desiring something more luxurious, but Hilton checks all the boxes for a comfortable, top-level stay in Peru's capital city.

Located just outside of downtown El Calafate, right along the lakefront, Xelena is a fantastic option for a full-service, high end Patagonia hotel to serve as a base for exploration in the area. The hotel offers a full range of amenities including a lovely indoor pool and restaurant, all with sweeping views of Lago Argentino. Many excellent restaurants in town are reachable via a short taxi ride, and walking along the lakeside boardwalk is a nice option for free afternoons and evenings.

Cumbres Lastarria offers a stylish, modern experience in a historic part of the city. Located in Santiago's Bohemian Lastarria neighborhood, Cumbres is a sanctuary in the middle of a bustling area on the edge of downtown. The area is full of chic bistros, shops and bars and is excellent for exploring on foot.